Prognostically Significant Fusion Oncogenes in Pakistani Patients with Adult Acute Lymphoblastic Leukemia and their Association with Disease Biology and Outcome

• DOI: 10.7314/apjcp.2012.13.7.3349
• Publication Date: 2013-02-22T07:57:15Z
• Authors: Noreen Sabir; Zafar Iqbal; Aamer Aleem; Tashfeen Awan; Tahir Naeem; Sultan Asad; Ammara H Tahir; Muhammad Absar; Rana MW Hasanato; Sulman Basit; Muhammad Azhar Ch...; Muhammad Faiyaz U...; Ahmad Muktar Khalid; Muhammad Farooq S...; Mahmood Rasool; Sajjad Karim; Mahwish Khan; Baila Samreen; Afia M Akram; Muhammad Hassan S...; Saba Shahzadi; Sana Shahbaz; Agha Shabbir Ali
• Keywords: ETV6; ABL; breakpoint cluster region; Hematology

Background and objectives: Chromosomal abnormalities play an important role in genesis of acute lymphoblastic leukemia (ALL) have prognostic implications. Five major risk stratifying fusion genes ALL are BCR-ABL, MLL-AF4, ETV6-RUNX11, E2A-PBX1 SIL-TAL1. This work aimed to detect common chromosomal translocations associated oncogenes adult patients study their relationship with clinical features treatment outcome. Methods: We studied 104 using RT-PCR interphase-FISH at diagnosis association characteristics Results: most i.e. BCR-ABL (t 9; 22), TCF3-PBX1 1; 19), ETV6-RUNX1 12; 21), MLL-AF4 4; 11) SIL-TAL1 (Del 1p32) were found 82/104 (79%) patients. gene was lymphadenopathy, positive had frequent organomegaly usually presented a platelets count less than <TEX>$50{\times}10^9/l$</TEX>. Survival better when compared harboring other genes. positivity characterized subset aggressive behaviour poor Conclusions: is the first from Pakistan which investigated frequency of5 patients, features, response Frequencies some different those reported elsewhere they appear be distinct information will help stratification adapted management