Triptolide Inhibits Histone Methyltransferase EZH2 and Modulates the Expression of Its Target Genes in Prostate Cancer Cells

• DOI: 10.7314/apjcp.2013.14.10.5663
• Publication Date: 2014-03-21T01:41:54Z
• Authors: Ousman Tamgue; Cheng-Sen Chai; Lin Hao; John-Clotaire Dag...; Wei-Wei Huang; Bin Zhang; Ming Lei; Yan-Ming Wei
• Keywords: Triptolide

The histone methyltransferase EZH2 (enhancer of zeste homolog 2) plays critical roles in prostate cancer (PCa) development and is a potential target for PCa treatment. Triptolide possesses anti-tumor activity, but it unknown whether its therapeutic effect relates with PCa. Here we described as cells. Our data showed that suppressed cell growth reduced the expression EZH2. Overexpression attenuated induced inhibition. Moreover, treatment PC-3 cells resulted elevated mRNA levels genes (ADRB2, CDH1, CDKN2A DAB2IP) negatively regulated by well levelsan positively gene (cyclin D1). findings suggest inhibition mediated might be associated downregulation subsequent modulation genes.