miR-19a Promotes Cell Growth and Tumorigenesis through Targeting SOCS1 in Gastric Cancer

• DOI: 10.7314/apjcp.2013.14.2.835
• Publication Date: 2013-08-09T02:03:46Z
• Authors: Shuang Qin; Fang Ai; Wei-Fang Ji; Wang Rao; He-Cheng Zhang; Wen-Jian Yao
• Keywords: Ectopic expression

Accumulating evidence has shown that microRNAs are involved in cancer development and progression. However, it remains unknown about the potential role of miR-19a pathogenesis gastric cancer. Here, we report suppressor cytokine signaling 1 (SOCS1) is a novel target cells expression inversely correlated with SOCS1 subset tissues. Ectopic dramatically promoted proliferation tumorigenicity both vitro vivo. Moreover, showed silencing cell growth colony formation resembling overexpression, whereas re-introduction (without 3'-UTR) attenuated pro-tumorigenic functions. Taken together, our findings suggest gene direct miR-19a, which functions as an oncogenic miRNA by repressing tumor SOCS1.