Multidisciplinary Collaborative Therapy for 30 Children with Orbital Rhabdomyosarcoma

• DOI: 10.7314/apjcp.2013.14.8.4641
• Publication Date: 2013-11-26T00:55:32Z
• Authors: Xin Ge; Dong-Sheng Huang; Ji-Tong Shi; Jian-Min Ma
• Keywords: Male; Clinical Trials as Topic; Adolescent; Infant; International Agencies; Prognosis; Combined Modality Therapy; 3. Good health; Survival Rate; 03 medical and health sciences; 0302 clinical medicine; Child, Preschool; Rhabdomyosarcoma; Humans; Orbital Neoplasms; Female; Cooperative Behavior; Child; Follow-Up Studies; Neoplasm Staging; Retrospective Studies

Objective: To explore clinical experience and propose new ideas for treating children diagnosed with orbital rhabdomyosarcoma (RMS). Methods: We retrospectively analyzed the data for30 patients (16 males 14 females, a median age of 6.2 years) primary RMS who were enrolled in Department Eye Oncology Pediatrics our hospital from November 2004 to December 2012. International Rhabdomyosarcoma Organization Staging Standards indicated that among 30 patients, 4 cases phase II, 20 III, 6 IV. All underwent multidisciplinary collaborative model comprehensive treatment (surgery, chemotherapy, external radiotherapy, <TEX>$^{125}I$</TEX> radioactive particle implantation, autologous peripheral blood stem-cell transplantation). Results: Follow-up was conducted until March 2013, follow-up time 47.2 months (5 95 months), 7 deaths occurred. The 2-year estimated survival rate reached 86.1%, <TEX>${\geq}3$</TEX>-year 77%, 5-year 70.6%. Conclusions: can be safe effective approach RMS. It has significance improving tumor remission rate.