Factors Predicting Microinvasion in Ductal Carcinoma in situ

• DOI: 10.7314/apjcp.2014.15.1.55
• Publication Date: 2014-07-01T10:40:31Z
• Authors: Sibel Ozkan-Gurdal; Neslihan Cabioglu; Beyza Ozcinar; Mahmut Muslumanoglu; Vahit Ozmen; Mustafa Kecer; Ekrem Yavuz; Abdullah Igci
• Keywords: Comedo; Micrometastasis

Background: Whether sentinel lymph node biopsy (SLNB) should be performed in patients with pure ductal carcinoma situ (DCIS) of the breast has been a question debate over last decade. The aim this study was to identify factors associated microinvasive disease and determine criteria for performing SLNB DCIS. Materials Methods: 125 DCIS who underwent surgery between January 2000 December 2008 were reviewed microinvasion (DCISM). Results: 88 (70.4%) had 37 (29.6%) DCISM. Among 33 SLNB, one patient (3.3%) found have isolated tumor cells her biopsy, whereas 1 14 (37.8%) DCISM micrometastasis (7.1%). Similarly, 16 (18.2%) axillary dissection (ALND) without none metastasis. Furthermore, 20 ALND, only (5%) In multivariate analysis, presence comedo necrosis [relative risk (RR)=4.1, 95% confidence interval (CI)=1.6-10.6, P=0.004], hormone receptor (ER or PR) negativity (RR=4.0, 95%CI=1.5-11, P=0.007), significantly microinvasion. Conclusions: Our findings suggest presenting preoperative diagnosis are more likely component definitive pathology following surgery, considered procedure along will undergo mastectomy due