Breast Cancer in Bedouin-Arab Patients in Southern Israel: Epidemiologic and Biologic Features in Comparison with Jewish Patients

• DOI: 10.7314/apjcp.2014.15.18.7533
• Publication Date: 2014-12-01T01:43:29Z
• Authors: Irina Lazarev; Maayan Flaschner; David B. Geffen; Samuel Ariad
• Keywords: Adult; Aged, 80 and over; Receptor, ErbB-2; Breast Neoplasms; Middle Aged; Prognosis; Arabs; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Receptors, Estrogen; Jews; Lymphatic Metastasis; Biomarkers, Tumor; Humans; Female; Neoplasm Invasiveness; Israel; Neoplasm Grading; Receptors, Progesterone; Aged; Follow-Up Studies; Neoplasm Staging

Background: Breast cancer (BC) is the most frequent type, and leading cause of death from among women in Israel. The Bedouin-Arab (BA) population southern Israel characterized by a high rate consanguinity, common hereditary disorders, transition semi-nomadic, traditional society to more sedentary urbanized society. In this hospital-based study, demographic clinicopathological characteristics BC BA were compared with Jewish patients. Materials Methods: 85 patients treated at Soroka Medical Center, Beer Sheba, during years 2004-2012, studied 180 consecutive year 2007. Clinicopathological features included age, menopausal state, number births, history first-degree relatives, tumor size (T), extent lymph-node involvement (N), distant metastases (M), stage, grade, estrogen progesterone receptor (ER/PR), Her2 status. Types treatment, relapse site, as well outcome also studied. Cox's regression models applied for studying disease-free, overall survival. Results: Compared patients, younger (average age <TEX>$49{\pm}12$</TEX> yrs vs <TEX>$59{\pm}13$</TEX>, p<0.001), had lower relatives (p<0.001), larger births (<TEX>$6{\pm}4.2$</TEX> <TEX>$2.5{\pm}1.9$</TEX>, p<0.001). tumors (p=0.02), extensive (p=0.002), advanced stage (p=0.003). Grade, ER, PR, status similar two ethnic groups. Relapse type was commonly systemic (p=0.05), loco-regional (p=0.02). Median survival 63, 35 months respectively (log-rank test, p=0.02). Cox multivariate analysis, PR (HR-0.14, p<0.0001; HR-3.11, p=0.046), but not ethnicity, influenced Conclusions: presents decade earlier, disease Biologic parameters including both Although prognosis worse than it affected only status, ethnicity.