Clinicopathology Profile and Bone Involvement of Multiple Myeloma Patients in Dharmais National Cancer Hospital, Indonesia

• DOI: 10.7314/apjcp.2015.16.15.6261
• Publication Date: 2015-12-11T12:57:50Z
• Authors: Noorwati Sutandyo; Evi Firna; Julyanti Agustina; Nugroho Prayogo; Leovinna Widjaja
• Keywords: Adult; Male; Spinal Neoplasms; L-Lactate Dehydrogenase; Femoral Neoplasms; Plasma Cells; Skull Neoplasms; Anemia; Cell Count; Humerus; Middle Aged; 3. Good health; 03 medical and health sciences; Cross-Sectional Studies; 0302 clinical medicine; Indonesia; Creatinine; Hypercalcemia; Humans; Female; Multiple Myeloma; Pelvic Bones; Hypoalbuminemia

Even though rarely found in Indonesia, the incidence of multiple myeloma (MM) is increasing every year. Bone involvement of MM is the most often a clinical disorder which leads to worsening clinical conditions and low quality of life of patients.To determine the clinicopathology profile of bone involvement of MM patients in Indonesia.The cross-sectional study of MM conducted at Dharmais National Cancer Hospital (DNCH) by collecting data from medical records of MM patients who came to DNCH in period 2008-2012.There were 39 MM patients all with age above 60 years. There were 56.4% male and 43.6% female patients. Most were diagnosed at stage III (32.4%), and 41% had obesity. The comorbid conditions were anemia (82.9%), hypoalbuminemia (60%), increased creatinine level (38.5%), increased β2 microglobulin level (94.1%), increased LDH level (23.1%) and plasmocytes above 30% (65%), but only 4.2% patients presented with hypercalcemia. Meanwhile, bone involvement occurred in 76.9% of MM patients with 4 lesions on average and a maximum of 16 lesions. The locations of bone lesions were spine (70%), skull (70%), pelvis (33.3%), humerus (30%), and femur (30%).The incidence of MM in Indonesia is increasing annually with bone involvement in more than three-fourths, but interestingly without hypercalcemia.