Prevalence of OCT1 (rs628031) genetic polymorphism in south Indian population

• DOI: 10.7324/japs.2021.1101006
• Publication Date: 2021-10-04T13:52:58Z
• Authors: Swathi Swaroopa B...; Bhavya Chebrolu; Poojitha Thotakura; Sujin Bright Fran...; Vasanth Raj Palan...; Sadagoban Gopal K...; Arun Kanniyappan ...
• Keywords: 0301 basic medicine; 03 medical and health sciences

Genetic polymorphism is defined as the presence of a heterozygous deoxyribose nucleic acid (DNA) variant in greater than 1% population. integrates genetic information clinical decision-making. High organic cation transporters (OCT) transport genes may represent significant portion variation pharmacokinetics and pharmacodynamics substrate drugs transported by OCT1. The scarcity research difference effect variability rs628031 various groups provide compelling reasons to perform study. purpose this study find prevalence South Indian phenol-chloroform technique was used extract DNA from 48 healthy individuals research. Polymerase chain reaction amplify acquired samples. After digestion with tailored restriction enzyme, fragment length utilized discover polymorphisms. minor allele frequency 0.67, indicating its deviation Hardy–Weinberg principle. alleles discovered comparable that seen Javanese study's major findings groundwork for future pharmacogenetic investigations group, well contribute better understanding role drug response benefit developing customized treatment regimen improved efficacy safety.