Pancreatic Cholera Syndrome: Effect of a Synthetic Somatostatin Analog on Intestinal Water and Ion Transport

• DOI: 10.7326/0003-4819-103-3-363
• Publication Date: 2013-04-12T15:21:47Z
• Authors: WILLIAM C. SANTAN...; THOMAS M. O'DORISIO; JONG G. KIM; GENE SEVERINO; GUENTER J. KREJS
• Keywords: Pancreatic polypeptide; Basal (medicine); Jejunum; Cholera; Short Bowel Syndrome

The effect of a synthetic somatostatin analog was studied in patient with severe secretory diarrhea due to pancreatic cholera syndrome. Basal intestinal perfusion studies indicated an absence water and sodium absorption, active chloride secretion the small bowel. Intravenous administration (1 µg/kg · h) changed zero net movement absorption (122 mL/30 cm jejunum per hour). Chloride (5.0 7.9 meq/30 h), plasma vasoactive polypeptide concentration reduced from 330 45 pmol/L (normal, less than 51). When given subcutaneously, 100 µg twice daily, stool weight decreased, fell toward normal range (67 pmol/L). Plasma initially elevated dropped during intravenous infusion but returned baseline on maintenance therapy delivered subcutaneously. has not had further 9 months therapy.