Factors Associated With Rates of False-Positive and False-Negative Results From Digital Mammography Screening: An Analysis of Registry Data

Breast Cancer Screening Digital Mammography False Negative Reactions Breast imaging
DOI: 10.7326/m15-0971 Publication Date: 2016-01-12T22:21:44Z
ABSTRACT
Background: Women screened with digital mammography may receive false-positive and false-negative results subsequent imaging biopsies. How these outcomes vary by age, time since the last screening, individual risk factors is unclear. Objective: To determine associated results, additional imaging, biopsies among a general population of women for breast cancer. Design: Analysis registry data. Setting: Participating facilities at 5 U.S. Breast Cancer Surveillance Consortium registries linkages to pathology databases tumor registries. Patients: 405 191 aged 40 89 years between 2003 2011. A total 2963 were diagnosed invasive cancer or ductal carcinoma in situ within 12 months screening. Measurements: Rates recommendations from single screening round; comparisons factors. Results: (121.2 per 1000 [95% CI, 105.6 138.7]) (124.9 [CI, 109.3 142.3]) highest 49 decreased increasing age. (1.0 1.5 women) biopsy (15.6 17.5 did not differ greatly Results False-positive rates higher factors, particularly family history cancer; previous benign result; high density; and, younger women, low body mass index. Limitations: Confounding variation patient-level characteristics across regions have been present. Some such as numbers first- second-degree relatives diagnoses examined. Conclusion: are common, those whereas occur less often. low. Primary Funding Source: Agency Healthcare Research Quality National Institute.
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