[Association between HLA-DRB1 gene polymorphisms and genetic susceptibility of early-onset severe preeclampsia].

• DOI: 10.7499/j.issn.1008-8830.2303100
• Publication Date: 2023-10-15
• Authors: Chun-Chi Lai; Lulu Zhang; Mengya Sun; Junfang Sun; Hong Jiang
• Keywords: SNP; Gene polymorphism

To explore the correlation between single nucleotide polymorphisms (SNP) of rs3135388, rs114293611 and rs142804168 HLA-DRB1 gene early-onset severe preeclampsia (sPE).Blood samples were collected from 102 sPE mothers their neonates (sPE group), as well 120 normotensive (control group). Sanger sequencing was performed to compare genotype distribution, allele frequencies, differences in distribution after maternal-infant compatibility two groups.Statistically significant at observed control groups both (P<0.05). The frequency T higher group than that (P<0.05), while no difference found (P>0.05). analysis showed There frequencies rs3135388 (P>0.05).The SNP may be associated with development mothers. Maternal-infant abnormality a predisposition factor for sPE.目的: 探讨HLA-DRB1基因rs3135388、rs114293611和rs142804168位点的单核苷酸多态性（single polymorphism, SNP）与早发型重度子痫前期（severe preeclampsia, sPE）的相关性。方法: 收集102例早发型sPE产妇及其新生儿（sPE组）和120例血压正常产妇及其新生儿（对照组）的血液标本进行Sanger测序，比较两组产妇及新生儿HLA-DRB1基因rs3135388、rs114293611和rs142804168位点基因型分布和等位基因频率及母婴配伍后基因型分布的差异。结果: HLA-DRB1基因rs114293611位点的基因型分布在sPE组和对照组产妇及新生儿之间差异均有统计学意义（P<0.05）。sPE组新生儿rs114293611位点T等位基因频率高于对照组，差异有统计学意义（P<0.05），而在两组产妇间差异无统计学意义（P>0.05）。rs114293611位点基因型母婴配伍后显示sPE组和对照组在基因型分布上差异有统计学意义（P<0.05）。HLA-DRB1基因rs3135388和rs142804168位点的基因型分布和等位基因频率在两组产妇及新生儿之间差异均无统计学意义（P>0.05）。结论: HLA-DRB1基因rs114293611位点SNP可能与产妇早发型sPE的发生相关。HLA-DRB1基因rs114293611位点母婴基因型配伍异常可能是产妇患早发型sPE的易感因素。.