effect of umbilical cord msc infusion on the pulmonary infection in haploidentical hematopoietic stem cell transplantation

• DOI: 10.7534/j.issn.1009-2137.2014.04.037
• Publication Date: 2014-08-01
• Authors: Zhi-Dong Wang; Li Ding; Jing Liu; Heng-Xiang Wang; Hong-Min Yan; Mei Xue; Dong-Mei Han; Ling Zhu; Xiao-Li Zheng
• Keywords: Adult; Lung Diseases; Male; Transplantation Conditioning; Adolescent; Hematopoietic Stem Cell Transplantation; Mesenchymal Stem Cells; Umbilical Cord; Young Adult; Treatment Outcome; Child, Preschool; Cytomegalovirus Infections; Humans; Transplantation, Homologous; Female; Child

This study was purposed to investigate the effect of umbilical cord mesenchymal cells (UC-MSC) infusion on the pulmonary infection in haploidentical hematopoietic stem cell transplantation (hi-HSCT). The infection of 83 patients underwent hi-HSCT was detected and analysed, among them 42 patients received haploidentical hi-HSCT, 41 received hi-HSCT combined with UC-MSC infusion. The results showed that 31 cases (73.81% ± 6.78%) were infected by cytomegalovirus and 21 cases in patients received hi-HSCT experienced pulmonary infections, including infections of fungal, virus, bacteria, tubercle bacillus, PCP and so on, the incidence rate was (50 ± 7.72)%; the infection of cytomegalovirus (CMV) was found in 31 cases, the incidence rate was (78.05 ± 6.46)%. In patients received hi-HSCT combined with UC-MSC, only 15 patients experienced pulmonary infection, the incidence rate was (36.59 ± 7.52)%, and the infection of cytomegalovirus (CMV) was observed in 32 patients, the incidence rate was (78.05 ± 6.46)%. There was no obvious statistical difference between two groups(P > 0.05). It is concluded that the UC-MSC infusion not increases the infection rate in hi-HSCT.