ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast

• DOI: 10.7554/elife.00422
• Publication Date: 2013-05-14T15:18:01Z
• Authors: Andrew Murley; Laura L Lackner; Christof Osman; Matthew West; Gia K Voeltz; Peter Walter; Jodi Nunnari
• Keywords: Nucleoid

Mitochondrial division is important for mitochondrial distribution and function. Recent data have demonstrated that ER–mitochondria contacts mark sites, but the molecular basis functions of these are not understood. Here we show in yeast, tethering complex, ERMES, highly conserved Miro GTPase, Gem1, spatially functionally linked to ER-associated division. Gem1 acts as a negative regulator contacts, an activity required spatial resolution newly generated tips following Previous ERMES localizes with subset actively replicating nucleoids. We nucleoids majority segregate prior division, resulting their into network. Thus, postulate serves link mitochondria cells.