Cell elongation is regulated through a central circuit of interacting transcription factors in the Arabidopsis hypocotyl

• DOI: 10.7554/elife.03031
• Publication Date: 2014-05-27T15:33:41Z
• Authors: Eunkyoo Oh; Jia-Ying Zhu; Ming-Yi Bai; Rafael Augusto Ar...; Yu Sun; Zhi-Yong Wang
• Keywords: Brassinosteroid; Photomorphogenesis; Crosstalk

As the major mechanism of plant growth and morphogenesis, cell elongation is controlled by many hormonal environmental signals. How these signals are coordinated at molecular level to ensure coherent cellular responses remains unclear. In this study, we illustrate a circuit that integrates all growth-regulating signals, including auxin, brassinosteroid, gibberellin, light, temperature. Analyses genome-wide targets, genetic biochemical interactions demonstrate auxin-response factor ARF6, light/temperature-regulated transcription PIF4, brassinosteroid-signaling BZR1, interact with each other cooperatively regulate large numbers common target genes, but their DNA-binding activities blocked gibberellin-inactivated repressor RGA. addition, tripartite HLH/bHLH module feedback regulates PIFs additional bHLH factors thereby modulates auxin sensitivity according developmental cues. Our results central growth-regulation hormonal, environmental, controls in Arabidopsis hypocotyl.