Cell elongation is regulated through a central circuit of interacting transcription factors in the Arabidopsis hypocotyl
0301 basic medicine
DNA, Plant
Light
QH301-705.5
Science
Arabidopsis
Plant Biology
crosstalk
03 medical and health sciences
Basic Helix-Loop-Helix Transcription Factors
Biology (General)
transcription factor
0303 health sciences
Indoleacetic Acids
Arabidopsis Proteins
Gene Expression Profiling
Q
R
Temperature
Nuclear Proteins
Hypocotyl
3. Good health
DNA-Binding Proteins
brassinosteroid
Medicine
auxin
light
Genome-Wide Association Study
Protein Binding
Signal Transduction
Transcription Factors
DOI:
10.7554/elife.03031
Publication Date:
2014-05-27T15:33:41Z
AUTHORS (6)
ABSTRACT
As the major mechanism of plant growth and morphogenesis, cell elongation is controlled by many hormonal and environmental signals. How these signals are coordinated at the molecular level to ensure coherent cellular responses remains unclear. In this study, we illustrate a molecular circuit that integrates all major growth-regulating signals, including auxin, brassinosteroid, gibberellin, light, and temperature. Analyses of genome-wide targets, genetic and biochemical interactions demonstrate that the auxin-response factor ARF6, the light/temperature-regulated transcription factor PIF4, and the brassinosteroid-signaling transcription factor BZR1, interact with each other and cooperatively regulate large numbers of common target genes, but their DNA-binding activities are blocked by the gibberellin-inactivated repressor RGA. In addition, a tripartite HLH/bHLH module feedback regulates PIFs and additional bHLH factors that interact with ARF6, and thereby modulates auxin sensitivity according to developmental and environmental cues. Our results demonstrate a central growth-regulation circuit that integrates hormonal, environmental, and developmental controls of cell elongation in Arabidopsis hypocotyl.
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