The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster

• DOI: 10.7554/elife.03191
• Publication Date: 2014-07-08T15:35:43Z
• Authors: Guiran Xiao; Zhihui Wan; Qiangwang Fan; Xiaona Tang; Bing Zhou
• Keywords: DMT1; Ferroportin

The intracellular iron transfer process is not well understood, and the identity of transporter responsible for delivery to secretory compartments remains elusive. In this study, we show Drosophila ZIP13 (Slc39a13), a presumed zinc importer, fulfills effluxing role. Interfering with dZIP13 expression causes iron-rescuable absorption defect, simultaneous increase in cytosol decrease compartments, failure ferritin loading, abnormal collagen secretion. E. coli confers upon host iron-dependent growth resistance. Importantly, time-coursed transport assays using an isotope indicated potent exporting activity dZIP13. identification as suggests that spondylocheiro dysplastic form Ehlers–Danlos syndrome, which hZIP13 defective, likely due compartments. Our results also broaden our knowledge scope defects from dyshomeostasis.