Functional effects of distinct innervation styles of pyramidal cells by fast spiking cortical interneurons

• DOI: 10.7554/elife.07919
• Publication Date: 2015-07-04T11:32:40Z
• Authors: Yoshiyuki Kubota; Satoru Kondo; Masaki Nomura; Sayuri Hatada; Noboru Yamaguchi; Alsayed A Mohamed; Fuyuki Karube; Joachim Lübke; Yasuo Kawaguchi
• Keywords: Pyramidal cell; Dendritic filopodia; Interneuron

Inhibitory interneurons target precise membrane regions on pyramidal cells, but differences in their functional effects somata, dendrites and spines remain unclear. We analyzed inhibitory synaptic events induced by cortical, fast-spiking (FS) basket cells which innervate dendritic shafts as well cell somata. Serial electron micrograph (EMg) reconstructions showed that somatic synapses were larger than contacts. Simulations with anatomical physiological data reveal between different innervation styles. FS soma-targeting initiate a strong, global inhibition, those inhibit more restricted zones, while may mediate strictly local veto. Thus, of sizes sites provide functionally diverse forms inhibition.