Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi
0301 basic medicine
571
Gene Transfer, Horizontal
QH301-705.5
Science
S. cerevisiae
Cell Cycle Proteins
virus
Evolution, Molecular
03 medical and health sciences
computational biology
evolution
chytrid
genomics
Biology (General)
0303 health sciences
evolutionary biology
Q
Cell Cycle
R
Fungi
systems biology
3. Good health
horizontal gene transfer
Medicine
cell cycle
fungi
Computational and Systems Biology
Transcription Factors
DOI:
10.7554/elife.09492
Publication Date:
2016-04-29T10:10:36Z
AUTHORS (5)
ABSTRACT
Although cell cycle control is an ancient, conserved, and essential process, some core animal and fungal cell cycle regulators share no more sequence identity than non-homologous proteins. Here, we show that evolution along the fungal lineage was punctuated by the early acquisition and entrainment of the SBF transcription factor through horizontal gene transfer. Cell cycle evolution in the fungal ancestor then proceeded through a hybrid network containing both SBF and its ancestral animal counterpart E2F, which is still maintained in many basal fungi. We hypothesize that a virally-derived SBF may have initially hijacked cell cycle control by activating transcription via the cis-regulatory elements targeted by the ancestral cell cycle regulator E2F, much like extant viral oncogenes. Consistent with this hypothesis, we show that SBF can regulate promoters with E2F binding sites in budding yeast.
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