Serotonin modulates infraslow oscillation in the dentate gyrus during Non-REM sleep

• DOI: 10.7554/elife.100196.3
• Publication Date: 2025-03-14T13:25:10Z
• Authors: Gergely F Turi; Sasa Teng; Xinyue Chen; Emily CY Lim; Carla Dias; Ruining Hu; Ruizhi Wang; Fenghua Zhen; Yueqing Peng
• Keywords: Sleep; Neuroscience of sleep; Sleep spindle; K-complex

Synchronous neuronal activity is organized into oscillations with various frequency and time domains across different brain areas states. For example, hippocampal theta, gamma sharp wave are critical for memory formation communication between subareas the cortex. In this study, we investigated of dentate gyrus (DG) optical imaging tools during sleep-wake cycles. We found that major glutamatergic cell populations in DG infraslow (0.01 – 0.03 Hz) NREM sleep. Although considered a sparsely active network wakefulness, 50% granule cells about 25% mossy exhibit increased sleep, compared to wakefulness. Further experiments revealed oscillation was correlated rhythmic serotonin release which oscillates at same but an opposite phase. Genetic manipulation 5-HT receptors neuromodulatory regulation mediated by 5-HT1a knockdown these leads impairment. Together, our results provide novel mechanistic insights how system can influence patterns