Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance

• DOI: 10.7554/elife.101413.1
• Publication Date: 2024-10-02T12:25:14Z
• Authors: Hans Kirschner; Hanna M Molla; Matthew R Nassar; Harriet de Wit; Markus Ullsperger
• Keywords: Baseline (sea); Dynamics

The ability to calibrate learning according new information is a fundamental component of an organism’s adapt changing conditions. Yet, the exact neural mechanisms guiding dynamic rate adjustments remain unclear. Catecholamines appear play critical role in adjusting degree which we use over time, but individuals vary widely manner they adjust changes. Here, studied effects low dose methamphetamine (MA), and individual differences these effects, on probabilistic reversal dynamics within-subject, double-blind, randomized design. Participants first completed task during drug-free baseline session provide measure performance. Then two sessions, one with MA (20 mg oral) placebo (PL). First, showed that, relative PL, modulates dynamically from prediction errors. Second, this effect was more pronounced participants who performed poorly at baseline. These results present novel evidence for involvement catecholaminergic transmission flexibility highlights that performance drug.