A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster
Male
0301 basic medicine
2. Zero hunger
QH301-705.5
Science
Q
R
Mutation, Missense
mitochondrial DNA
Cell Biology
DNA, Mitochondrial
male fertility
sperm development
Electron Transport Complex IV
Mitochondrial Proteins
03 medical and health sciences
Drosophila melanogaster
Infertility
Medicine
Animals
experimental evolution
Biology (General)
lifespan
genetic suppressors
DOI:
10.7554/elife.16923
Publication Date:
2016-08-01T23:59:23Z
AUTHORS (10)
ABSTRACT
Due to their strict maternal inheritance in most animals and plants, mitochondrial genomes are predicted to accumulate mutations that are beneficial or neutral in females but harmful in males. Although a few male-harming mtDNA mutations have been identified, consistent with this ‘Mother’s Curse’, their effect on females has been largely unexplored. Here, we identify COIIG177S, a mtDNA hypomorph of cytochrome oxidase II, which specifically impairs male fertility due to defects in sperm development and function without impairing other male or female functions. COIIG177S represents one of the clearest examples of a ‘male-harming’ mtDNA mutation in animals and suggest that the hypomorphic mtDNA mutations like COIIG177S might specifically impair male gametogenesis. Intriguingly, some D. melanogaster nuclear genetic backgrounds can fully rescue COIIG177S -associated sterility, consistent with previously proposed models that nuclear genomes can regulate the phenotypic manifestation of mtDNA mutations.
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