Reactive oxygen species-dependent Toll/NF-κB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism

• DOI: 10.7554/elife.25496
• Publication Date: 2017-10-30T14:00:12Z
• Authors: Isabelle Louradour; Anurag Sharma; Ismael Morin-Poulard; Manon Letourneau; Alain Vincent; Michèle Crozatier; Nathalie Vanzo
• Keywords: Hematopoietic stem cell

Hematopoietic stem/progenitor cells in the adult mammalian bone marrow ensure blood cell renewal. Their cellular microenvironment, called 'niche', regulates hematopoiesis both under homeostatic and immune stress conditions. In Drosophila hematopoietic organ, lymph gland, posterior signaling center (PSC) acts as a niche to regulate response such wasp parasitism. This relies on differentiation of lamellocytes, cryptic type, dedicated pathogen encapsulation killing. Here, we establish that Toll/NF-κB pathway activation PSC parasitism non-cell autonomously induces gland response. Our data further regulatory network where co-activation EGFR by ROS levels PSC/niche controls Whether similar operates mammals control emergency is an open question.