Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells

• DOI: 10.7554/elife.28875
• Publication Date: 2017-12-04T12:01:10Z
• Authors: Pedro Lee; Rupali Gund; Abhik Dutta; Neha Pincha; Isha Rana; Subhasri Ghosh; Deborah Witherden; Eve Kandyba; Amanda MacLeod; Krzysztof Kobielak; Wendy L Havran; Colin Jamora
• Keywords: Epidermis (zoology); Skin repair

The cutaneous wound-healing program is a product of complex interplay among diverse cell types within the skin. One fundamental process that mediated by these reciprocal interactions mobilization local stem pools to promote tissue regeneration and repair. Using ablation epidermal caspase-8 as model wound healing in Mus musculus, we analyzed signaling components responsible for epithelial proliferation. We found IL-1α IL-7 secreted from keratinocytes work tandem expand activated population resident γδT-cells. A downstream effect γδT-cells preferential proliferation hair follicle cells. By contrast, IL-1α-dependent stimulation dermal fibroblasts optimally stimulates These findings provide new mechanistic insights into regulation function cell–immune how are classically associated with inflammation can differentially influence distinct niches tissue.