Bidirectional encoding of motion contrast in the mouse superior colliculus
Male
0301 basic medicine
vision
Superior Colliculi
QH301-705.5
Science
Motion Perception
Gene Expression
superior colliculus
Mice
Motion
03 medical and health sciences
Genes, Reporter
Orientation
direction selectivity
Animals
Biology (General)
GABAergic Neurons
center-surround interactions
Visual Cortex
saliency
Glutamate Decarboxylase
Q
R
Molecular Imaging
Mice, Inbred C57BL
Luminescent Proteins
Medicine
Female
Visual Fields
two-photon imaging
Photic Stimulation
Neuroscience
Red Fluorescent Protein
DOI:
10.7554/elife.35261
Publication Date:
2018-07-02T12:08:29Z
AUTHORS (4)
ABSTRACT
Detection of salient objects in the visual scene is a vital aspect of an animal’s interactions with its environment. Here, we show that neurons in the mouse superior colliculus (SC) encode visual saliency by detecting motion contrast between stimulus center and surround. Excitatory neurons in the most superficial lamina of the SC are contextually modulated, monotonically increasing their response from suppression by the same-direction surround to maximal potentiation by an oppositely-moving surround. The degree of this potentiation declines with depth in the SC. Inhibitory neurons are suppressed by any surround at all depths. These response modulations in both neuronal populations are much more prominent to direction contrast than to phase, temporal frequency, or static orientation contrast, suggesting feature-specific saliency encoding in the mouse SC. Together, our findings provide evidence supporting locally generated feature representations in the SC, and lay the foundations towards a mechanistic and evolutionary understanding of their emergence.
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