Effects of spinal cord stimulation on postural control in Parkinson's disease patients with freezing of gait

• DOI: 10.7554/elife.37727
• Publication Date: 2018-08-02T12:03:01Z
• Authors: Andrea Cristina d...; Daniel Boari Coelho; Carolina Pinto Souza; Carolina Oliveira...; Maria Gabriela do...; Tiago Garcia; Mariana Voos; Matija Milosevic; Clement Hamani; Luis Augusto Teix...; Erich Talamoni Fo...
• Keywords: Male; QH301-705.5; Science; 03 medical and health sciences; 0302 clinical medicine; Humans; Biology (General); Gait; Postural Balance; parkinsonism; Gait Disorders, Neurologic; Aged; Spinal Cord Stimulation; Q; R; Motor Cortex; balance; Parkinson Disease; Middle Aged; 3. Good health; postural instability and gait disorders (PIGD); Spinal Cord; gait analysis; neuromodulation; Medicine; Female; Brazil; Neuroscience

Freezing of gait (FoG) in Parkinson's disease (PD) is an incapacitating transient phenomenon, followed by continuous postural disorders. Spinal cord stimulation (SCS) a promising intervention for FoG patients with PD, however, its effects on distinct domains control not well known. The aim this study to assess the SCS and control. Four were implanted systems upper thoracic spine. Anticipatory adjustment (APA), reactive responses, biomechanically assessed. In general, results showed that improved APA. However, failed improve responses. seems influence cortical motor circuits, involving supplementary area. On other hand, posture external perturbation mainly relies neuronal circuitries brainstem spinal cord, less influenced SCS.