Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources

• DOI: 10.7554/elife.39234
• Publication Date: 2018-10-09T12:00:27Z
• Authors: Bram Cerulus; Abbas Jariani; Gemma Perez-Samper; Lieselotte Vermee...; Julian MJ Pietsch; Matthew M Crane; Aaron M New; Brigida Gallone; Miguel Roncoroni; Maria C Dzialo; Sander K Govers; Jhana O Hendrickx; Eva Galle; Maarten Coomans; Pieter Berden; Sara Verbandt; Peter S Swain; Kevin J Verstrepen
• Keywords: Life Sciences & Biomedicine - Other Topics; 0301 basic medicine; Saccharomyces cerevisiae Proteins; Time Factors; QH301-705.5; Science; Genes, Fungal; Carbohydrates; NUCLEAR-PORE COMPLEX; SIGNAL-TRANSDUCTION; Cell Count; Saccharomyces cerevisiae; YEAST SACCHAROMYCES-CEREVISIAE; CATABOLITE INACTIVATION; cellular memory; GLUCOSE; 03 medical and health sciences; Oxygen Consumption; Gene Expression Regulation, Fungal; single-cell analysis; Gene Regulatory Networks; RNA, Messenger; Biology (General); Biology; GAL GENES; Cell Nucleus; Science & Technology; Gene Expression Profiling; Q; R; ENVIRONMENTAL-CHANGES; Aerobiosis; Carbon; TRANSCRIPTIONAL MEMORY; CELLULAR MEMORY; Fermentation; Mutation; lag phase; Medicine; glucose repression; gene regulation; Life Sciences & Biomedicine; metabolic shift; MALTOSE TRANSPORTER; Computational and Systems Biology

Cells constantly adapt to environmental fluctuations. These physiological changes require time and therefore cause a lag phase during which the cells do not function optimally. Interestingly, past exposure an condition can shorten needed when re-occurs, even in daughter that never directly encountered initial condition. Here, we use molecular toolbox of Saccharomyces cerevisiae systematically unravel mechanism underlying such history-dependent behavior transitions between glucose maltose. In contrast previous hypotheses, does depend on persistence proteins involved metabolism specific sugar. Instead, presence induces gradual decline cells’ ability activate respiration, is metabolize alternative carbon sources. results reveal how trans-generational central generate yeast, provide mechanistic framework for similar phenomena other cell types.