Offline impact of transcranial focused ultrasound on cortical activation in primates

• DOI: 10.7554/elife.40541
• Publication Date: 2019-02-12T00:00:15Z
• Authors: Lennart Verhagen; Cécile Gallea; Davide Folloni; Charlotte Constans; Daria EA Jensen; Harry Ahnine; Léa Roumazeilles; Mathieu Santin; Bashir Ahmed; Stéphane Lehericy; Miriam C Klein-Fl...; Kristine Krug; Rogier B Mars; Matthew FS Rushworth; Pierre Pouget; Jean-François Aubry; Jerome Sallet
• Keywords: Brain stimulation; Motor area

To understand brain circuits it is necessary both to record and manipulate their activity. Transcranial ultrasound stimulation (TUS) a promising non-invasive technique. date, investigations report short-lived neuromodulatory effects, but deliver on its full potential for research therapy, protocols are required that induce longer-lasting ‘offline’ changes. Here, we present TUS protocol modulates activation in macaques more than one hour after 40 s of stimulation, while circumventing auditory confounds. Normally activity areas reflects interconnected regions caused stimulated interact selectively with the rest brain. In within-subject design, observe regionally specific effects two medial frontal – supplementary motor area polar cortex. Independently these site-specific also induced signal changes meningeal compartment. were temporary not associated microstructural