Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle

• DOI: 10.7554/elife.44876
• Publication Date: 2019-04-23T12:02:15Z
• Authors: Qingnian Goh; Taejeong Song; Michael J Petrany; Alyssa AW Cramer; Chengyi Sun; Sakthivel Sadayappan; Se-Jin Lee; Douglas P Millay
• Keywords: Compensatory hypertrophy

Skeletal muscle adapts to external stimuli such as increased work. Muscle progenitors (MPs) control repair due severe damage, but the role of MP fusion and associated myonuclear accretion during exercise are unclear. While we previously demonstrated that is required for growth using a supra-physiological model (Goh Millay, 2017), questions remained about need accrual adaptation in physiological setting. Here, developed an 8 week high-intensity interval training (HIIT) protocol assessed importance fusion. In month-old mice, HIIT led progressive throughout protocol, functional hypertrophy. Abrogation at onset resulted intolerance fibrosis. contrast, ablation 4 weeks into HIIT, preserved tolerance attenuated We conclude different facets exercise-induced adaptive responses, impacting both hypertrophic growth.