Cerebellar climbing fibers encode expected reward size

• DOI: 10.7554/elife.46870
• Publication Date: 2019-10-29T13:00:47Z
• Authors: Noga Larry; Merav Yarkoni; Adi Lixenberg; Mati Joshua
• Keywords: Climbing; Climbing fiber; ENCODE; Reward system; Cued speech; Associative learning

Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently, evidence has accumulated suggest is also involved in processing of reward. To study how rewarding events are encoded, we recorded activity climbing fibers when monkeys were engaged an eye movement task. At beginning each trial, cued size reward would be delivered upon successful completion trial. increased presented with a cue indicating large reward, but not small Reward did modulate at delivery or during movements. Comparison between and simple spike indicated different interactions for coding These results indicate expected general role associative learning beyond correction.