Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adult Drosophila

• DOI: 10.7554/elife.48264
• Publication Date: 2019-06-19T12:00:17Z
• Authors: Noa Bielopolski; Hoger Amin; Anthi A Apostolop...; Eyal Rozenfeld; Hadas Lerner; Wolf Huetteroth; Andrew C Lin; Moshe Parnas
• Keywords: Mushroom bodies; Associative learning

Olfactory associative learning in Drosophila is mediated by synaptic plasticity between the Kenyon cells of mushroom body and their output neurons. Both inputs from projection neurons are cholinergic, yet little known about physiological function muscarinic acetylcholine receptors adult flies. Here, we show that aversive olfactory flies requires type A (mAChR-A), particularly gamma subtype cells. mAChR-A inhibits odor responses localized cell dendrites. Moreover, knockdown impairs learning-associated depression a neuron. Our results suggest dendrites required for