Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

• DOI: 10.7554/elife.48448
• Publication Date: 2019-10-21T12:37:33Z
• Authors: Carolyn M Walsh; Rose Z Hill; Jamie Schwendinge...; Jacques Deguine; Emily C Brock; Natalie Kucirek; Ziad Rifi; Jessica Wei; Karsten Gronert; Rachel B Brem; Gregory M Barton; Diana M Bautista
• Keywords: CXCR3; Scratching

Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic diseases are thought to be driven by both the nervous and immune systems, but fundamental molecular cellular interactions that trigger development of acute-to-chronic transition remain unknown. Here, we show skin-infiltrating neutrophils key initiators in atopic dermatitis, most disorder. Neutrophil depletion significantly attenuated itch-evoked scratching mouse model dermatitis. Neutrophils were also required for several hallmarks itch, including skin hyperinnervation, enhanced expression signaling molecules, upregulation inflammatory cytokines, activity-induced genes, markers neuropathic itch. Finally, demonstrate induction CXCL10, ligand CXCR3 receptor promotes via activation sensory neurons, find antagonism attenuates