Perinatal hormones favor CC17 group B Streptococcus intestinal translocation through M cells and hypervirulence in neonates

• DOI: 10.7554/elife.48772
• Publication Date: 2019-11-11T13:00:25Z
• Authors: Constantin Hays; Gérald Touak; Abdelouhab Bouaboud; Agnès Fouet; Julie Guignot; Claire Poyart; Asmaa Tazi
• Keywords: Group B; Neonatal meningitis; clone (Java method); Neonatal Infection

Group B Streptococcus (GBS) is the leading cause of invasive bacterial neonatal infections. Late-onset diseases (LOD) occur between 7 and 89 days life are largely due to CC17 GBS hypervirulent clone. We studied impact estradiol (E2) progesterone (P4), which impregnate fetus during pregnancy, on infection in cellular mouse models hormonal exposure corresponding concentrations found at birth (E2-P4 C0) over old C7). Using representative isolates, we show that E2-P4 C7 specifically favor meningitis following mice oral infection. crosses intestinal barrier through M cells. This process mediated by CC17-specific surface protein Srr2 enhanced promote cell differentiation invasiveness. Our findings provide an explanation for responsibility LOD link with gastrointestinal tract maturation imprint.