Quantitative properties of a feedback circuit predict frequency-dependent pattern separation

• DOI: 10.7554/elife.53148
• Publication Date: 2020-02-20T14:00:12Z
• Authors: Oliver Braganza; Daniel Mueller-Ko...; Tony Kelly; Heinz Beck
• Keywords: Feed forward; Negative feedback; Separation (statistics); Facilitation

Feedback inhibitory motifs are thought to be important for pattern separation across species. How feedback circuits may implement of biologically plausible, temporally structured input in mammals is, however, poorly understood. We have quantitatively determined key properties netfeedback inhibition the mouse dentate gyrus, a region critically involved separation. is recruited steeply with low dynamic range (0% 4% active GCs), and non-uniform spatial profile. Additionally, net shows frequency-dependent facilitation, driven by strongly facilitating mossy fiber inputs. Computational analyses show significant contribution circuit theta modulated inputs, even within individual cycles. Moreover, was selectively boosted at gamma frequencies, particular highly similar This effect robust, suggesting that feature microcircuit.