A mammalian Wnt5a–Ror2–Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis

• DOI: 10.7554/elife.53688
• Publication Date: 2020-05-12T09:00:57Z
• Authors: Kuan Zhang; Erica Yao; Chuwen Lin; Yu-Ting Chou; Julia Wong; Jianying Li; Paul J Wolters; Pao-Tien Chuang
• Keywords: Chronic Obstructive; Biomedical and clinical sciences; QH301-705.5; Science; Organogenesis; 610; planar cell polarity; Nerve Tissue Proteins; Ligands; Receptor Tyrosine Kinase-like Orphan Receptors; Wnt-5a Protein; lung; Pulmonary Disease; Mesoderm; developmental biology; Mice; Pulmonary Disease, Chronic Obstructive; 03 medical and health sciences; 616; Morphogenesis; Animals; Humans; Biology (General); alveolar epithelial cell; Myofibroblasts; alveolus; Cell Shape; Lung; mouse; Cytoskeleton; Platelet-Derived Growth Factor; 0303 health sciences; Q; R; Health sciences; Cell Polarity; Endothelial Cells; cytoskeleton; Actomyosin; Biological Sciences; myofibroblast; Pulmonary Alveoli; Biological sciences; Alveolar Epithelial Cells; Medicine; Biochemistry and Cell Biology; Signal Transduction; Developmental Biology

Alveolar formation increases the surface area for gas-exchange and is key to physiological function of lung. epithelial cells, myofibroblasts endothelial cells undergo coordinated morphogenesis generate folds (secondary septa) form alveoli. A mechanistic understanding alveologenesis remains incomplete. We found that planar cell polarity (PCP) pathway required in alveolar mammals. Our studies uncovered a