GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation

• DOI: 10.7554/elife.59079
• Publication Date: 2020-10-02T12:00:17Z
• Authors: Ming Li; Zhongyu Xie; Jinteng Li; Jiajie Lin; Guan Zheng; Wenjie Liu; Su'an Tang; Shuizhong Cen; Guiwen Ye; Zhaofeng Li; Wenhui Yu; Peng Wang; Yanfeng Wu; Huiyong Shen
• Keywords: GAS5

Osteoporosis is a common systemic skeletal disorder resulting in bone fragility and increased fracture risk. It still necessary to explore its detailed mechanisms identify novel targets for the treatment of osteoporosis. Previously, we found that lncRNA named GAS5 human could negatively regulate lipoblast/adipocyte differentiation. However, it unclear whether affects osteoblast differentiation associated with Our current research was decreased bones BMSCs, major origin osteoblast, osteoporosis patients. Mechanistically, promotes by interacting UPF1 degrade SMAD7 mRNA. Moreover, mass impaired repair ability were observed Gas5 heterozygous mice, manifesting The supplement -overexpressing adenoviruses significantly ameliorated loss an mouse model. In conclusion, targeting UPF1/SMAD7 axis protects against