MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

• DOI: 10.7554/elife.60191
• Publication Date: 2021-01-08T14:03:08Z
• Authors: Tessa M Popay; Jing Wang; Clare M Adams; Gregory Caleb Howard; Simona G Codreanu; Stacy D Sherrod; John A McLean; Lance R Thomas; Shelly L Lorey; Yuichi J Machida; April M Weissmiller; Christine M Eischen; Qi Liu; William P Tansey
• Keywords: ribosome biogenesis; Proto-Oncogene Proteins c-myc

The oncoprotein transcription factor MYC is a major driver of malignancy and highly validated but challenging target for the development anticancer therapies. Novel strategies to inhibit may come from understanding co-factors it uses drive pro-tumorigenic gene expression programs, providing their role in activity understood. Here we interrogate how one co-factor, host cell (HCF)–1, contributes human Burkitt lymphoma setting. We identify genes connected mitochondrial function ribosome biogenesis as direct MYC/HCF-1 targets demonstrate modulation MYC–HCF-1 interaction influences growth, metabolite profiles, global patterns, tumor growth vivo. This work defines HCF-1 critical places biological context, highlights focal point novel anti-MYC