Evolution of the complex transcription network controlling biofilm formation in Candida species

• DOI: 10.7554/elife.64682
• Publication Date: 2021-04-07T12:02:57Z
• Authors: Eugenio Mancera; Isabel Nocedal; Stephen Hammel; Megha Gulati; Kaitlin F Mitchell; David R Andes; Clarissa J Nobile; Geraldine Butler; Alexander D Johnson
• Keywords: Transcription

We examine how a complex transcription network composed of seven 'master' regulators and hundreds target genes evolved over span approximately 70 million years. The controls biofilm formation in several Candida species, group fungi that are present humans both as constituents the microbiota opportunistic pathogens. Using variety approaches, we observed two major types changes have occurred since four extant species examined last shared common ancestor. Master regulator 'substitutions' relatively long evolutionary times, resulting different having overlapping but sets master formation. Second, massive connections between their much shorter timescales. believe this analysis is first detailed, empirical description has evolved.