IGF-1 facilitates extinction of conditioned fear

• DOI: 10.7554/elife.67267
• Publication Date: 2021-04-01T14:00:19Z
• Authors: Laura E Maglio; José A Noriega-Pr...; Irene B Maroto; Jesús Martin-Cort...; Antonio Muñoz-Cal...; Marta Callejo-Mós...; David Fernández d...
• Keywords: Nonsynaptic plasticity; Extinction (optical mineralogy); Infralimbic cortex

Insulin-like growth factor-1 (IGF-1) plays a key role in synaptic plasticity, spatial learning, and anxiety-like behavioral processes. While IGF-1 regulates neuronal firing transmission many areas of the central nervous system, its signaling consequences on excitability, animal behavior dependent prefrontal cortex remain unexplored. Here, we show that induces long-lasting depression medium slow post-spike afterhyperpolarization (mAHP sAHP), increasing excitability layer 5 pyramidal neurons rat infralimbic cortex. Besides, mediates presynaptic long-term both inhibitory excitatory these neurons. The net effect this IGF-1-mediated plasticity is potentiation postsynaptic potentials. Moreover, demonstrate favors fear extinction memory. These results novel functional signaling, revealing as element control