Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

• DOI: 10.7554/elife.67460
• Publication Date: 2021-06-22T00:00:28Z
• Authors: Nguyen Lam Vuong; Phung Khanh Lam; Damien Keng Yen Ming; Huynh Thi Le Duyen; Nguyet Minh Nguyen; Dong Thi Hoai Tam; Kien Duong Thi Hue; Nguyen VV Chau; Ngoun Chanpheaktra; Lucy Chai See Lum; Ernesto Pleités; Cameron P Simmons; Kerstin D Rosenbe...; Thomas Jaenisch; David Bell; Nathalie Acestor; Christine Halleux; Piero L Olliaro; Bridget A Wills; Ronald B Geskus; Sophie Yacoub
• Keywords: Triage

Background: Early identification of severe dengue patients is important regarding patient management and resource allocation. We investigated the association 10 biomarkers (VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, CRP) with development severe/moderate (S/MD). Methods: performed a nested case-control study from multi-country study. A total 281 S/MD 556 uncomplicated cases were included. Results: On days 1–3 symptom onset, higher levels any biomarker increased risk developing S/MD. When assessing together, SDC-1 IL-1RA stable, while IP-10 changed positive to negative; others showed weaker associations. The best combinations associated comprised for children, sCD163 adults. Conclusions: Our findings assist panels clinical use could improve triage prediction in patients. Funding: This was supported by EU's Seventh Framework Programme (FP7-281803 IDAMS), WHO, Bill Melinda Gates Foundation.