Epigenome-wide analysis of DNA methylation and coronary heart disease: a nested case-control study

• DOI: 10.7554/elife.68671
• Publication Date: 2021-09-13T12:00:29Z
• Authors: Jiahui Si; Songchun Yang; Dianjianyi Sun; Canqing Yu; Yu Guo; Yifei Lin; Iona Y Millwood; Robin G Walters; Ling Yang; Yiping Chen; Huaidong Du; Yujie Hua; Jingchao Liu; Junshi Chen; Zhengming Chen; Wei Chen; Jun Lv; Liming Liang; Liming Li
• Keywords: Epigenome; Nested case-control study; Epigenomics

Identifying environmentally responsive genetic loci where DNA methylation is associated with coronary heart disease (CHD) may reveal novel pathways or therapeutic targets for CHD. We conducted the first prospective epigenome-wide analysis of in relation to incident CHD Asian population.