Correlation between leukocyte phenotypes and prognosis of amyotrophic lateral sclerosis

• DOI: 10.7554/elife.74065
• Publication Date: 2022-02-28T15:00:20Z
• Authors: Can Cui; Caroline Ingre; Li Yin; Xia Li; John Andersson; Christina Seitz; Nicolas Ruffin; Yudi Pawitan; Fredrik Piehl; Fang Fang
• Keywords: amyotrophic lateral sclerosis; 0303 health sciences; QH301-705.5; Science; Q; Amyotrophic Lateral Sclerosis; R; CD8-Positive T-Lymphocytes; 03 medical and health sciences; immune cells; Immunology and Inflammation; Phenotype; Disease Progression; Leukocytes; blood flow; Medicine; Humans; prognosis; Longitudinal Studies; Biology (General)

The prognostic role of immune cells in amyotrophic lateral sclerosis (ALS) remains undetermined. Therefore, we conducted a longitudinal cohort study including 288 ALS patients with up to 5-year follow-up during 2015–2020 recruited at the only tertiary referral center for Stockholm, Sweden, and measured levels differential leukocytes lymphocyte subpopulations. primary outcome was risk death after diagnosis secondary outcomes included functional status disease progression rate. Cox model used evaluate associations between death. Generalized estimating equation assess correlation We found that leukocytes, neutrophils, monocytes increased gradually over time since were negatively correlated status, but not associated or For subpopulations, NK (HR= 0.61, 95% CI = [0.42–0.88] per SD increase) Th2-diffrentiated CD4 + central memory T 0.64, [0.48–0.85] death, while effector re-expressing CD45RA (EMRA) 1.39, [1.01–1.92] CD8 1.38, [1.03–1.86] positively None subpopulations Our findings suggest dual prognosis, where neutrophils primarily reflect whereas different populations act as markers survival.