Internally generated time in the rodent hippocampus is logarithmically compressed

• DOI: 10.7554/elife.75353
• Publication Date: 2022-10-17T10:15:13Z
• Authors: Rui Cao; John H Bladon; Stephen J Charczy...; Michael E Hasselmo; Marc W Howard
• Keywords: Time line

The Weber-Fechner law proposes that our perceived sensory input increases with physical on a logarithmic scale. Hippocampal ‘time cells’ carry record of recent experience by firing sequentially during circumscribed period time after triggering stimulus. Different cells have fields’ at different delays up to least tens seconds. Past studies suggest represent compressed timeline demonstrating fewer fire late in the delay and their fields are wider. This paper asks whether compression obeys Law. Time were studied hierarchical Bayesian model simultaneously accounts for pattern trial level, cell population level. procedure allows separate estimates within-trial receptive field width across-trial variability. After isolating variability, increased linearly delay. Further, was distributed evenly along axis. These findings provide strong quantitative evidence neural temporal representation rodent hippocampus is logarithmically