Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

• DOI: 10.7554/elife.76211
• Publication Date: 2022-05-17T00:00:30Z
• Authors: Nataliia Kozhemiako; Jun Wang; Chenguang Jiang; Lei A Wang; Guanchen Gai; Kai Zou; Zhe Wang; Xiaoman Yu; Lin Zhou; Shen Li; Zhenglin Guo; Robert Law; James Coleman; Dimitrios Mylonas; Lu Shen; Guoqiang Wang; Shuping Tan; Shengying Qin; Hailiang Huang; Michael Murphy; Robert Stickgold; Dara Manoach; Zhenhe Zhou; Wei Zhu; Mei-Hua Hal; Shaun M Purcell; Jen Q Pan
• Keywords: Neurophysiology

Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key non-rapid eye movement (NREM) sleep parameters across multiple domains, their interdependencies, and relationship waking event-related potentials symptom severity. In 72 schizophrenia (SCZ) 58 controls, confirmed a marked reduction spindle density SCZ extended these findings show that fast slow properties were largely uncorrelated. We also describe novel measure oscillation interaction was attenuated SCZ. The main replicated demographically distinct sample, joint model, based on NREM components, statistically predicted disease status replication cohort. Although altered patients, auditory elicited during wake unrelated metrics. Consistent growing literature implicating dysfunction SCZ, our characterization identifies independent EEG biomarkers may aspects pathophysiology point neural mechanisms underlying heterogeneity. This study lays groundwork for evaluating markers, individually or combination, guide efforts at treatment prevention as well identifying individuals most likely benefit from specific interventions.