A single-cell atlas of the cycling murine ovary

• DOI: 10.7554/elife.77239
• Publication Date: 2022-10-07T12:01:40Z
• Authors: Mary E Morris; Marie-Charlotte M...; Maeva Chauvin; Hatice D Saatcioglu; Aki Kashiwagi; Natalie A Sicher; Ngoc Nguyen; Selena Yuan; Rhian Stavely; Minsuk Hyun; Patricia K Donahoe; Bernardo L Sabatini; David Pépin
• Keywords: Ovulation; 0301 basic medicine; 0303 health sciences; QH301-705.5; estrous cycle; Science; Q; Ovary; R; Estrous Cycle; single-cell RNA sequencing; Pelvis; Mice; 03 medical and health sciences; Ovarian Follicle; Medicine; Animals; ovary; Female; Biology (General); mouse; Developmental Biology

The estrous cycle is regulated by rhythmic endocrine interactions of the nervous and reproductive systems, which coordinate hormonal ovulatory functions ovary. Folliculogenesis follicle progression require orchestrated response a variety cell types to allow maturation its sequela, ovulation, corpus luteum formation, wound repair. Little known about state dynamics ovary during paracrine factors that help this process. Herein, we used single-cell RNA sequencing evaluate transcriptome >34,000 cells adult mouse describe transcriptional changes occur across normal other states build comprehensive dynamic atlas murine ovarian states.