A single-cell atlas of the cycling murine ovary

Ovulation 0303 health sciences QH301-705.5 estrous cycle Science Q Ovary R Estrous Cycle single-cell RNA sequencing Pelvis Mice 03 medical and health sciences Ovarian Follicle Medicine Animals ovary Female Biology (General) mouse Developmental Biology
DOI: 10.7554/elife.77239 Publication Date: 2022-10-07T12:01:40Z
ABSTRACT
The estrous cycle is regulated by rhythmic endocrine interactions of the nervous and reproductive systems, which coordinate the hormonal and ovulatory functions of the ovary. Folliculogenesis and follicle progression require the orchestrated response of a variety of cell types to allow the maturation of the follicle and its sequela, ovulation, corpus luteum formation, and ovulatory wound repair. Little is known about the cell state dynamics of the ovary during the estrous cycle and the paracrine factors that help coordinate this process. Herein, we used single-cell RNA sequencing to evaluate the transcriptome of >34,000 cells of the adult mouse ovary and describe the transcriptional changes that occur across the normal estrous cycle and other reproductive states to build a comprehensive dynamic atlas of murine ovarian cell types and states.
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