A single-cell atlas of the cycling murine ovary

Ovulation 0301 basic medicine 0303 health sciences QH301-705.5 estrous cycle Science Q Ovary R Estrous Cycle single-cell RNA sequencing Pelvis Mice 03 medical and health sciences Ovarian Follicle Medicine Animals ovary Female Biology (General) mouse Developmental Biology
DOI: 10.7554/elife.77239 Publication Date: 2022-10-07T12:01:40Z
ABSTRACT
The estrous cycle is regulated by rhythmic endocrine interactions of the nervous and reproductive systems, which coordinate hormonal ovulatory functions ovary. Folliculogenesis follicle progression require orchestrated response a variety cell types to allow maturation its sequela, ovulation, corpus luteum formation, wound repair. Little known about state dynamics ovary during paracrine factors that help this process. Herein, we used single-cell RNA sequencing evaluate transcriptome >34,000 cells adult mouse describe transcriptional changes occur across normal other states build comprehensive dynamic atlas murine ovarian states.
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