Towards a unified model of naive T cell dynamics across the lifespan
Dynamics
Naive T cell
Cd4 t cell
DOI:
10.7554/elife.78168
Publication Date:
2022-06-09T12:00:30Z
AUTHORS (5)
ABSTRACT
Naive CD4 and CD8 T cells are cornerstones of adaptive immunity, but the dynamics their establishment early in life how kinetics change as they mature following release from thymus poorly understood. Further, due to diverse signals implicated naive cell survival, it has been a long-held conceptually attractive view that sustained by active homeostatic control thymic activity wanes. Here we use multiple modelling experimental approaches identify unified model population mice, across lifespan. We infer both subsets divide rarely, progressively increase survival capacity with age. Strikingly, this simple is able describe throughout life. In contrast, find newly generated lost more rapidly during first 3–4 weeks life, likely increased recruitment into memory. no evidence for elevated division rates neonates, or feedback regulation numbers at any show confronting mathematical models datasets can reveal quantitative remarkably picture mice birth old
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (58)
CITATIONS (16)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....