Towards a unified model of naive T cell dynamics across the lifespan

• DOI: 10.7554/elife.78168
• Publication Date: 2022-06-09T12:00:30Z
• Authors: Sanket Rane; Thea Hogan; Edward Lee; Benedict Seddon; Andrew J Yates
• Keywords: Dynamics; Naive T cell; Cd4 t cell

Naive CD4 and CD8 T cells are cornerstones of adaptive immunity, but the dynamics their establishment early in life how kinetics change as they mature following release from thymus poorly understood. Further, due to diverse signals implicated naive cell survival, it has been a long-held conceptually attractive view that sustained by active homeostatic control thymic activity wanes. Here we use multiple modelling experimental approaches identify unified model population mice, across lifespan. We infer both subsets divide rarely, progressively increase survival capacity with age. Strikingly, this simple is able describe throughout life. In contrast, find newly generated lost more rapidly during first 3–4 weeks life, likely increased recruitment into memory. no evidence for elevated division rates neonates, or feedback regulation numbers at any show confronting mathematical models datasets can reveal quantitative remarkably picture mice birth old