Rhythmic coordination and ensemble dynamics in the hippocampal-prefrontal network during odor-place associative memory and decision making

• DOI: 10.7554/elife.79545
• Publication Date: 2022-12-08T13:00:19Z
• Authors: Claire A Symanski; John H Bladon; Emi T Kullberg; Paul Miller; Shantanu P Jadhav
• Keywords: Cued speech

Memory-guided decision making involves long-range coordination across sensory and cognitive brain networks, with key roles for the hippocampus prefrontal cortex (PFC). In order to investigate mechanisms of such coordination, we monitored activity in (CA1), PFC, olfactory bulb (OB) rats performing an odor-place associative memory guided task on a T-maze. During odor sampling, beta (20–30 Hz) respiratory (7–8 rhythms (RR) were prominent three regions, RR coherence between all pairs regions enhanced during odor-cued period. Beta phase modulation phase-locked CA1 PFC neurons this period was linked accurate decisions, role interneurons temporal coordination. Single ensembles both encoded predicted animals’ upcoming choices, different cell engaged decision-making execution maze. Our findings indicate that rhythmic within hippocampal-prefrontal-olfactory network supports utilization cues memory-guided making.