Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex

• DOI: 10.7554/elife.81863
• Publication Date: 2023-05-30T12:00:40Z
• Authors: Mean-Hwan Kim; Cristina Radaelli; Elliot R Thomsen; Deja Monet; Thomas Chartrand; Nikolas L Jorstad; Joseph T Mahoney; Michael J Taormina; Brian Long; Katherine Baker; Trygve E Bakken; Luke Campagnola; Tamara Casper; Michael Clark; Nick Dee; Florence D'Orazi; Clare Gamlin; Brian E Kalmbach; Sara Kebede; Brian R Lee; Lindsay Ng; Jessica Trinh; Charles Cobbs; Ryder P Gwinn; C Dirk Keene; Andrew L Ko; Jeffrey G Ojemann; Daniel L Silbergeld; Staci A Sorensen; Jim Berg; Kimberly A Smith; Philip R Nicovich; Tim Jarsky; Hongkui Zeng; Jonathan T Ting; Boaz P Levi; Ed Lein
• Keywords: Neocortex; Cell type; Human brain

Rodent studies have demonstrated that synaptic dynamics from excitatory to inhibitory neuron types are often dependent on the target cell type. However, these cell-specific properties not been well investigated in human cortex, where there major technical challenges reliably obtaining healthy tissue, conducting multiple patch-clamp recordings types, and identifying those types. Here, we take advantage of newly developed methods for neurosurgical tissue analysis with recordings,