The rostral intralaminar nuclear complex of the thalamus supports striatally mediated action reinforcement
Action selection
DOI:
10.7554/elife.83627
Publication Date:
2023-04-06T11:00:19Z
AUTHORS (4)
ABSTRACT
The dorsal striatum (DS) mediates the selection of actions for reward acquisition necessary survival. Striatal pathology contributes to several neuropsychiatric conditions, including aberrant specific rewards in addiction. A major source glutamate driving striatal activity is rostral intralaminar nuclei (rILN) thalamus. Yet, information that relayed support action unknown. Here, we discovered rILN neurons projecting DS are innervated by a range cortical and subcortical afferents rILN→DS stably signaled at two time points mice performing an sequence task reinforced sucrose reward: initiation acquisition. In vivo activation this pathway increased number successful trials, whereas inhibition decreased trials. These findings illuminate role nuclear complex reinforcing actions.
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