The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

• DOI: 10.7554/elife.84628.1
• Publication Date: 2023-02-03T14:53:53Z
• Authors: Lukas M. Weber; Heena R. Divecha; Matthew N. Tran; Sang Ho Kwon; Abby Spangler; Kelsey D. Montgomery; Madhavi Tippani; Rahul Bharadwaj; Joel E. Kleinman; Stephanie C. Page; Thomas M. Hyde; Leonardo Collado-...; Kristen R. Maynard; Keri Martinowich; Stephanie C. Hicks
• Keywords: Locus coeruleus; Human brain

Norepinephrine (NE) neurons in the locus coeruleus (LC) project widely throughout central nervous system, playing critical roles arousal and mood, as well various components of cognition including attention, learning, memory. The LC-NE system is also implicated multiple neurological neuropsychiatric disorders. Importantly, are highly sensitive to degeneration both Alzheimer’s Parkinson’s disease. Despite clinical importance brain region prominent role a variety behavioral functions, detailed molecular characterization LC lacking. Here, we used combination spatially-resolved transcriptomics single-nucleus RNA-sequencing characterize landscape transcriptomic profile human brain. We provide freely accessible resource these data web-accessible formats.