Manganese-enhanced magnetic resonance imaging reveals light-induced brain asymmetry in embryo
0301 basic medicine
Manganese
Gallus gallus domesticus; MEMRI; brain; chicken; embryonic development; lateralization; neuroscience
QH301-705.5
brain
Science
Q
R
MEMRI
Brain
Embryo, Mammalian
Magnetic Resonance Imaging
3. Good health
Gallus gallus domesticus
03 medical and health sciences
0302 clinical medicine
embryonic development
lateralization
Medicine
Animals
Biology (General)
Chickens
Neuroscience
DOI:
10.7554/elife.86116
Publication Date:
2023-09-05T13:20:11Z
AUTHORS (4)
ABSTRACT
The idea that sensory stimulation to the embryo (in utero or in ovo) may be crucial for brain development is widespread. Unfortunately, up to now evidence was only indirect because mapping of embryonic brain activity in vivo is challenging. Here, we applied for the first time manganese enhanced magnetic resonance imaging (MEMRI), a functional imaging method, to the eggs of domestic chicks. We revealed light-induced brain asymmetry by comparing embryonic brain activity in vivo of eggs that were stimulated by light or maintained in the darkness. Our protocol paves the way to investigation of the effects of a variety of sensory stimulations on brain activity in embryo.
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CITATIONS (8)
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