A dynamical computational model of theta generation in hippocampal circuits to study theta-gamma oscillations during neurostimulation

• DOI: 10.7554/elife.87356.2
• Publication Date: 2024-01-11T12:25:14Z
• Authors: Nikolaos Vardalakis; Amélie Aussel; Nicolas P. Rougier; Fabien B. Wagner
• Keywords: Neurostimulation; Reset (finance)

Neurostimulation of the hippocampal formation has shown promising results for modulating memory but underlying mechanisms remain unclear. In particular, effects on theta-nested gamma oscillations and theta phase reset, which are both crucial processes, unknown. Moreover, these cannot be investigated using current computational models, consider with a fixed amplitude velocity. Here, we developed novel model that includes medial septum, represented as set abstract Kuramoto oscillators producing dynamical rhythm formation, composed biophysically-realistic neurons able to generate under drive. We showed that, inputs just below threshold induce self-sustained oscillations, single stimulation pulse could switch network behavior from non-oscillatory state sustained oscillations. Next, demonstrated weaker input, train at frequency transiently restore seemingly physiological Importantly, presence reset influenced whether two depended onset was delivered, practical implications designing neurostimulation protocols triggered by ongoing This opens new avenues studying formation. Furthermore, our hybrid approach combines different levels abstraction extended in future work other neural circuits produce brain rhythms.